Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases.
Cleaning up misfolded proteins
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Dr John Christianson's research focusses on ER-associated degradation, which is responsible for clearing non-functional and orphan translation products. These processes play a central role in inherited diseases such a cystic fibrosis and various forms of cancer. Dr Christianson's long term goal is to identify novel points of interventions for cancer therapies.
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