January 2024 Cara Murphy

Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Assistant Professor Cara Murphy, clinical psychologist at Brown University. Cara Murphy works at the Center for Alcohol and Addiction in the School of Public Health and the Center for Addiction and Disease Risk Exacerbation.

Jamie Hartmann-Boyce interviews Cara Murphy about her new trial, Trial for Harm Reduction With Incentives & Vaping E-cigarettes (THRIVE) and funded by the National Institute of General Medical Sciences. This trial will assess the effect of e-cigarettes and incentives on combustible cigarette smoking in individuals with overweight/obesity who smoke cigarettes. A randomized group of participants will given e-cigarettes for 6 weeks. carbon monoxide will be monitored and participants will either receive fixed incentives for sample completion or receive varying incentives contingent on their carbon monoxide levels. Researchers will compare groups to understand the effect of each condition on smoking-related behaviour. Cara outlines how individuals with overweight/obesity who smoke cigarettes have greatly increased risks of metabolic, cardiac, and pulmonary diseases due to the synergistic effects of tobacco and obesity. Cara also discusses issues faced by people who smoke and are overweight. Switching to e-cigarettes may decrease the risk of negative health outcomes and be a promising approach.

This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches.

Our literature searches carried out on 1st December and 1st January found the following .
1 new study by Xu et el 2023 (Xu Y, Goldenson NI, Prakash S Augustson EM, Shiffman S, Randomized trial assessing the effect of the JUUL system on switching away from cigarettes and smoking reduction among U.S. adults who smoke cigarettes. Experimental and clinical psychopharmacology / 2023;(9419066)).
2 new ongoing studies: NCT06111053, Trial for Harm Reduction With Incentives & Vaping E-cigarettes (https://clinicaltrials.gov/study/NCT06111053) and
NCT06118502, A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse (ADAPT) (https://clinicaltrials.gov/study/NCT06118502).
1 study by Pope et al 2023 linked to Notley 2023 (Pope I, Notley C, Boyle A, Results of the cessation of smoking trial in the emergency department (COSTED), Emergency Medicine Journal / 2023;40(12):873-874).

For further details see our webpage under 'Monthly search findings':
https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-ces...

For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/...

This podcast is supported by Cancer Research UK.